Protein Modification Reagents
Medchemexpress LLC Pomalidomide-5'-PEG8-C2-COOH | 2138440-78-3 | 98.2% | 697.73 g/mol | C32H47N3O14 | 25 MG
Pomalidomide-5'-PEG8-C2-COOH is an E3 ligase ligand-linker conjugate designed as a building block for PROTAC synthesis. It combines a pomalidomide CRBN-binding moiety with an 8-unit PEG linker and a C2 carboxylic acid handle to enable conjugation to target ligands.
- useful building block for proteolysis-targeting chimeras (PROTACs).
- high purity suitable for synthetic applications.
- soluble in DMSO at approximately 100 mg/mL.
- molecular weight about 697.73 g/mol and formula C32H47N3O14.
- storage: pure form -20°C (3 years) or 4°C (2 years).
Medchemexpress LLC Mal-Ph-CONH-PEG4-NHS ester | 1263044-88-7 | ≥97.0% | 561.54 g/mol | C26H31N3O11 | 250 MG
Mal-Ph-CONH-PEG4-NHS ester is a non-cleavable, 4-unit polyethylene glycol (PEG4) NHS ester linker used for the synthesis of antibody-drug conjugates (ADCs). It provides a maleimide-phenyl reactive group and an NHS-activated ester to enable conjugation between payloads and antibodies in research applications.
- Non-cleavable 4-unit PEG linker.
- Maleimide-phenyl group for thiol-selective coupling.
- NHS ester for efficient amine conjugation.
- High purity (≥97.0%).
- Available in small pack sizes including 250 mg.
- Liquid form, colorless to light yellow.
- Storage: pure form -20°C (stable for 3 years); in solvent -80°C (6 months), -20°C (1 month).
Medchemexpress LLC 2,5,8,11-Tetraoxatridecane, 13-azido- | 606130-90-9 | 98.0% | C9H19N3O4 | 50 MG
2,5,8,11-Tetraoxatridecane, 13-azido- is a chemical compound with a molecular weight of 233.26. It appears as a colorless to light yellow liquid and is intended for research use only. This product has been tested and complies with the given specifications.
- Colorless to light yellow liquid appearance
- Molecular weight of 233.26
- Suitable for research applications
- Storage in pure form at -20°C for 3 years
- Storage in solvent at -80°C for 6 months
- Storage in solvent at -20°C for 1 month
Medchemexpress LLC DBCO-PEG4-NHS ester | 1427004-19-0 | 99.0% | C34H39N3O10 | 25 MG
DBCO-PEG4-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that possess Azide groups.
- PEG-based PROTAC linker
- Click chemistry reagent
- Contains a DBCO group for SPAAC with Azide groups
- For research use only
Avanti Polar Lipids DSPE-PEG(2000)MALEIMIDE 100MG
1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)-2000] (ammonium salt). 474922-22-0
Medchemexpress LLC DBCO-PEG3-Glu-VC-PABC-MMAF | 2253947-24-7 | 1 MG
DBCO-PEG3-Glu-VC-PABC-MMAF is a drug-linker conjugate for Antibody-Drug Conjugates (ADCs). It utilizes the tubulin inhibitor MMAF, linked via a cathepsin cleavable DBCO-PEG3-Glu-VC-PABC. This compound can be used in the synthesis of ADCs, which consist of an antibody to which an ADC cytotoxin is attached through an ADC linker.
- Drug-linker conjugate for Antibody-Drug Conjugates (ADCs)
- Uses tubulin inhibitor MMAF
- Linked via cathepsin cleavable DBCO-PEG3-Glu-VC-PABC
- Can be used in the synthesis of ADCs
- For research use only
Medchemexpress LLC (S,R,S)-AHPC-PEG4-NH2 hydrochloride | 2064292-52-8 | 98.2% | 700.29 g/mol | C32H50ClN5O8S | 50 MG
(S,R,S)-AHPC-PEG4-NH2 hydrochloride is a synthesized E3 ligase VHL ligand-linker conjugate used as a PROTAC building block. It combines an (S,R,S)-configured AHPC VHL ligand with a four-unit PEG linker terminating in a primary amine, providing a conjugation handle for assembling bifunctional degraders.
- VHL ligand core for recruiting the VHL E3 ligase.
- Four-unit PEG linker imparts flexibility and improves solubility.
- Terminal primary amine enables straightforward conjugation to warheads or linkers.
- High purity suitable for research synthesis (≈98.2%).
- Water solubility up to 50 mg/mL (ultrasonic may be required) for formulation convenience.
- Supplied as a hydrochloride salt to aid stability and handling.
- Intended for use as a PROTAC intermediate in targeted protein degradation research.
Medchemexpress LLC Biotin-PEG2-C2-iodoacetamide | 292843-75-5 | 98.23% | C18H31IN4O5S | 50 MG
Biotin-PEG2-C2-iodoacetamide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
eMolecules 2112731-44-7 | N-Boc-PEG9-alcohol | Broadpharm | MFCD30723250 | 513.625 | C23H47NO11 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 343283756
N-Boc-PEG9-alcohol | Broadpharm | 2112731-44-7 | MFCD30723250 | 513.625 | C23H47NO11 | 98.000 | CC(C)(C)OC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCO | 1g | 343283756
Cambridge Isotope Laboratories GLYCAN-O6-13C-GAL4 (GALACTOSE-13C6, 99%), 500 PMOL
GLYCAN-O6-13C-GAL4 (GALACTOSE-13C6, 99%), 500 PMOL
Medchemexpress LLC DBCO-PEG4-NHS ester | 1427004-19-0 | 99.0% | C34H39N3O10 | 1 G
DBCO-PEG4-NHS ester is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This product is intended for research use only.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Reacts with azide-containing molecules
- Exploits the intracellular ubiquitin-proteasome system to selectively degrade target proteins
- For research use only
eMolecules 557756-85-1 | Fmoc-N-amido-PEG4-acid | Combi-Blocks | MFCD06656472 | 487.549 | C26H33NO8 | 97.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 10g | 388716220
Fmoc-N-amido-PEG4-acid | Combi-Blocks | 557756-85-1 | MFCD06656472 | 487.549 | C26H33NO8 | 97.000 | OC(=O)CCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 10g | 388716220
![eMolecules N-(acid-PEG24)-N-bis(PEG3-azide) | Broadpharm |1548.818 | C67H133N7O32 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCN=[N+]=[N-] | 100mg | 563055202](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502480768.JPG-250.jpg)
eMolecules N-(acid-PEG24)-N-bis(PEG3-azide) | Broadpharm |1548.818 | C67H133N7O32 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCN=[N+]=[N-] | 100mg | 563055202
N-(acid-PEG24)-N-bis(PEG3-azide) | Broadpharm |1548.818 | C67H133N7O32 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN(CCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCN=[N+]=[N-] | 100mg | 563055202
![eMolecules 1821017-46-2 | Methyltetrazine-Sulfo-NHS ester | Broadpharm | MFCD29052195 | 429.340 | C15H12N5NaO7S | 95.000 | [Na+].Cc1nnc(nn1)-c1ccc(CC(=O)ON2C(=O)CC(C2=O)S([O-])(=O)=O)cc1 | 10mg | 296213298](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502464935.JPG-250.jpg)
eMolecules 1821017-46-2 | Methyltetrazine-Sulfo-NHS ester | Broadpharm | MFCD29052195 | 429.340 | C15H12N5NaO7S | 95.000 | [Na+].Cc1nnc(nn1)-c1ccc(CC(=O)ON2C(=O)CC(C2=O)S([O-])(=O)=O)cc1 | 10mg | 296213298
Methyltetrazine-Sulfo-NHS ester | Broadpharm | 1821017-46-2 | MFCD29052195 | 429.340 | C15H12N5NaO7S | 95.000 | [Na+].Cc1nnc(nn1)-c1ccc(CC(=O)ON2C(=O)CC(C2=O)S([O-])(=O)=O)cc1 | 10mg | 296213298